Effects of various medicaments on the oxygen consumption of the blood corpuscles.

Mitsuo Tanno (丹 野 三 男) From Prof. F. Nakazawa's Internal Clinic, Medical Department, Tohoku University, Sendai (Received for publication, April 9, 1956) From the studies of Morawitz1) and Warburg2) it is evident that , like other tissues or cells, the blood corpuscles taken out of living bodies but kept at blood temperature exercise, as one of their vital phenomena, respiration by themselves, consuming oxygen and emitting carbonic acid gas, and that this respiration is not the exchange of gases made by nuclear elements such as the red blood corpuscles with nuclei or the white blood corpuscles, but is chiefly effected by the red blood corpuscles, especially the young ones, has also been established.3)'4) And the mechanism to take part in this respiration lies chiefly in their stroma and particularly glycolysis in the blood corpuscles is an important factor in it.5) I tried the experiments reported hereunder in order to examine what effects the various medicines such as miscellaneous antibiotic substances, sulfonamid, nitrogen mustard, folic acid, thiouracil and tetraethyl ammonium bormide have on the respiration of the blood corpuscles, and made an attempt to explain the working mechanism of these medicines on living and cells.